Molecular and functional characterization of the endothelial ATP-sensitive potassium channel
نویسندگان
چکیده
منابع مشابه
Endothelial biology and ATP-sensitive potassium channels
ATP sensitive potassium (KATP) channels are metabolic sensors with channel activity promoted by decreases in ATP andnor increases in MgADP. The most studied are channels present in cardiac myocytes and pancreatic b cells but KATP currents also exist more widely in a range of tissues and organs [1,2]. The channel is a hetero-octamer comprising four sulphonylurea receptors and four pore-forming i...
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OBJECTIVE Endothelial dysfunction is an early risk factor for cardiovascular disease and hypertension. Mechanisms that participate in endothelial dysfunction include reduced nitric oxide (NO) generation and increased endothelin-1 (ET-1) generation. Endothelial ATP-sensitive potassium (K(ATP)) channels are responsible for maintaining the resting potential of endothelial cells and modulating the ...
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Neonatal diabetes mellitus (NDM) is a monogenic disorder caused by mutations in genes involved in regulation of insulin secretion from pancreatic β-cells. Mutations in the KCNJ11 and ABCC8 genes, encoding the adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channel Kir6.2 and SUR1 subunits, respectively, are found in ∼50% of NDM patients. In the pancreatic β-cell, K(ATP) channel activi...
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ATP-sensitive potassium (K(ATP)) channels couple cellular metabolic status to changes in membrane electrical properties. Caffeine (1,2,7-trimethylxanthine) has been shown to inhibit several ion channels; however, how caffeine regulates K(ATP) channels was not well understood. By performing single-channel recordings in the cell-attached configuration, we found that bath application of caffeine s...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2017
ISSN: 0021-9258
DOI: 10.1074/jbc.m117.810325